The Effect of the Mahkota Dewa (Phaleria macrocarpa) on the Density of Collagen Incision Wounds

Abstract

Wounds are a disorder in the continuity of the skin or mucosal epithelial layer, which is a result of physical or thermal damage The research purpose was to analyze effect of mahkota dewa (Phaleria macrocarpa) on the density of collagen incision wound of white rats (Rattus norvegicus). This research has used post test only control group design. The sample were 30 male rats that grouped into control (K1, K2, K3) and treatment (P1, P2, P3) groups. The control group was given 1%CMC, while the treatment group was given oral extract of mahkota dewa at a dose of 22.5 mg/kg bw. The data was analyzed by Kruskall Wallis test. The results showed that there were a significant difference of collagen density between control and treatment group. The mahkota dewa fruits extract increased the macrophage activity. Thus, the macrophage activity could increase the Transforming Growth Factor - ß (TGF-ß) secretion. The TGF-ß could stimulate fibroblast prolipheration. In addition, collagen synthesis could increased. Based on the results, Mahkota dewa (Phaleria macrocarpa) extract could increase the collagen density of incision wound of white rats (Rattus norvegicus).