Lymphocytic insulitis in a 'non-obese diabetic (NOD)' strain of mice: An immunohistochemical and electron microscope investigation

113Citations
Citations of this article
9Readers
Mendeley users who have this article in their library.

Abstract

Pathohistological changes were investigated in the pancreas of a recently inbred 'non-obese diabetic (NOD) mouse' which becomes diabetic due to severe insulitis which resembles that in human juvenile onset or Type I diabetes. In 4 and 5 week old mice, pancreatic islets are infiltrated by lymphocytes. This lymphocytic insulitis selectively and progressively destroys the B cells of pancreatic islets. The diabetic symptoms appear when most of the B cells have been lost. The circulation route and the nature of the infiltrating lymphocytes, as well as the cytological changes in the B and other islet cells were studied by light and electron microscopy, Immunohistochemistry for insulin, glucagon, somatostatin and pancreatic polypeptide, has added information on the process leading to the disappearance of insulin and the behavior of the islet cells containing other hormones.

Cite

CITATION STYLE

APA

Fujita, T., Yui, R., & Kusumoto, Y. (1982). Lymphocytic insulitis in a “non-obese diabetic (NOD)” strain of mice: An immunohistochemical and electron microscope investigation. Biomedical Research, 3(4), 429–443. https://doi.org/10.2220/biomedres.3.429

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free