RNA viruses are capable of rapid spread and severe or potentially lethal disease in both animals and humans. The development of reverse genetics systems for manipulation and study of RNA virus genomes has provided platforms for designing and optimizing viral mutants for vaccine development. Here, we review the impact of RNA virus reverse genetics systems on past and current efforts to design effective and safe viral therapeutics and vaccines. © 2014 by the authors; licensee MDPI, Basel, Switzerland.
CITATION STYLE
Stobart, C. C., & Moore, M. L. (2014, June 25). RNA virus reverse genetics and vaccine design. Viruses. MDPI AG. https://doi.org/10.3390/v6072531
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