Seroprevalence of hepatitis E virus (HEV) antibody and the possible association with chronic liver disease: A case-control study in Albania

24Citations
Citations of this article
27Readers
Mendeley users who have this article in their library.

Abstract

A case-control study involving 109 in-patients with chronic liver disease and 190 in-patients with no apparent liver disease was conducted to evaluate the seroprevalence of anti-HEV antibodies and the possible association with chronic liver disease. Among cases, the anti-HEV prevalence was 36.6% which increased significantly by age; among controls, the prevalence was 12.1% (P<0.05) and was similar among age groups <60 years. Among cases, aged >50 years (OR 4.0, 95% CI 1.4-11) and the presence of end stage liver disease (ESLD) (OR 4.3, 95% CI 1.4-12.8) were associated independently with anti-HEV positivity. The mean optical density, determined by anti-HEV immunoenzymatic test, was significantly higher among patients with ESLD, compared to the other patients. These results indicate that there is a high seroprevalence of anti-HEV in patients with chronic liver disease and a possible association between HEV infection and/or anti-HEV production and advanced stage chronic liver disease. © 2005 Cambridge University Press.

Cite

CITATION STYLE

APA

Kondili, L. A., Chionne, P., Porcaro, A., Madonna, E., Taffon, S., Resuli, B., … Rapicetta, M. (2006). Seroprevalence of hepatitis E virus (HEV) antibody and the possible association with chronic liver disease: A case-control study in Albania. Epidemiology and Infection, 134(1), 95–101. https://doi.org/10.1017/S095026880500470X

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free