1069 YOUNG WOMEN WITH SHORT SLEEP DURATION AND INSOMNIA RUN A HIGH RISK OF DEVELOPING HYPERTENSION AND DIABETES MELLITUS. A 10-YEAR FOLLOW-UP OF THE POPULATION-BASED SHE STUDY.

Abstract

Introduction: We aimed to study whether sleep duration, and insomnia are risk factors for incident hypertension and diabetes mellitus in women. Methods: At baseline and at 10-year follow-up, a random sample of 4,404 women aged 20–87 years without hypertension or diabetes at baseline answered questionnaires on sleep duration (short; <6h/night, normal; 6-<9h/night), insomnia (difficulty inducing sleep (DIS), difficulty maintaining sleep (DMS) or early morning awakening (EMA)), anthropometric measures, lifestyle factors and somatic disease. Outcome was incident hypertension and diabetes at the 10-year follow-up. Age stratified multivariate analysis were adjusted for baseline BMI, smoking, physical activity, and alcohol dependency. Results: The incidence of hypertension and diabetes were lowest in the reference group with normal sleep duration and no insomnia (10.7% and 2.1%, respectively). The highest incidence was seen in women with short sleep duration both with insomnia (hypertension: 16.5%, and diabetes: 4.7%) and without insomnia (hypertension: 21.3%, and diabetes: 4.2%). Women younger than 40 years with short sleep duration alone had the highest risk of incident hypertension with adjusted OR 3.8 (95%CI 1.3–11.5) in the multivariate analysis. Women younger than 40 years with the combination of short sleep duration and insomnia had the highest risk of developing diabetes with adjusted OR 8.1 (2.1–30.9). Conclusion: Short sleep duration and the risk for diabetes and hypertension is age dependent in women. Young women -below 40 years- with short sleep duration and insomnia run a high risk of developing diabetes mellitus, while young women with short sleep duration alone run a high risk to develop hypertension. The different risk combination regarding insomnia, or not, indicate different possible underlying mechanisms when women with short sleep duration develop diabetes and hypertension. Support (If Any): The SHE study is supported financially by the Swedish Heart Lung Foundation. The authors have no conflicts of interest.