Microfluidic electrochemical detection techniques of cancer biomarkers

Abstract

Microfluidic electrochemical sensors are based on the immune response. Immune charge density or electrode potential and other parameters sensitive interface causes a change or cause a power solution of the active ingredient (or their related components) to generate or consume, causing the detected current or potential. The electrochemical parameters of the law of changing enable the immune proteins quantitative or qualitative detection. Since the immune protein molecules themselves are typically non-electrochemical activity, and therefore immune electrochemical sensor usually mark the electrically active substance or enzyme in the antigen or antibody molecules in solution antigen (antibody) immune response and by the immobilized antigen (antibody) the concentration of the sample antigen (antibody) after the change of the current signal, causing the electro-active substance or enzyme-catalyzed reaction of substrate reaction can be determined indirectly.