IL-6 is a pleiotropic cytokine that participates in normal functions of the immune system, haematopoiesis, metabolism, as well as in the pathogenesis of metabolic and cardiovascular diseases. Both pro- and anti-inflammatory roles of IL-6 have been described, which are distinguished by different cascades of signalling transduction, namely classic and trans-signalling. The present review summarizes the basic principles of IL-6 signalling and discusses its roles in diabetes and associated cardiovascular complications, with emphasis on the different outcomes mediated by the two modes of IL-6 signalling and the value of developing therapeutic strategies to specifically target the deleterious trans-signalling of IL-6. © 2014 The British Pharmacological Society.
CITATION STYLE
Qu, D., Liu, J., Lau, C. W., & Huang, Y. (2014). IL-6 in diabetes and cardiovascular complications. British Journal of Pharmacology. John Wiley and Sons Inc. https://doi.org/10.1111/bph.12713
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