Syntheses and Antibacterial Activities of Penem Derivatives

Abstract

This article is intended to give a brief review of synthetic methods of penems, ranging from Woodward's first penem synthesis to the most recent penem synthesis appearing in current papers. The antibacterial in vitro activities of a variety of penem derivatives are also described, together with structure-activity relationships of penems prepared in our laboratories. © 1983, The Society of Synthetic Organic Chemistry, Japan. All rights reserved.