Abstract
Taking into consideration immunogenicity in humans, human antibodies and their derivatives have potential advantages for cancer immunotherapy and/or gene therapy over those from different species such as mouse. Recently, we generated 22 human monoclonal antibodies (HmAbs) specific for human carcinoembryonic antigen (CEA) using KM mouse, which carries human antibody genes. In the present study, we tried to clone the variable (V) region genes of the C2-45 HmAb, with the highest affinity for CEA and to generate a human single-chain variable fragmented (scFv) antibody.
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Lianos, K., Schonberger, J. L., Pollefeys, M., & Sattler, T. (2018). VSO: Visual Semantic Odometry Konstantinos-Nektarios. European Conference on Computer Vision, 11220, 111–127. Retrieved from http://link.springer.com/10.1007/978-3-030-01216-8%0Ahttp://link.springer.com/10.1007/978-3-030-01270-0
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