Synthesis of fused quinazolinethiones and their S-alkyl/aryl derivatives

Abstract

Quinazoline derivatives are associated with broad spectrum of biological activities. In view of this, 4-substituted phenyl-3,4,5,6-tetrahydrobenzo[h] quinazoline-2(1H)-thiones were prepared under microwave irradiations through one-pot multicomponent reactions and these quinazolinethiones were then converted to S-alkyl/aryl quinazoline derivatives. The synthetic schemes of the prepared compounds are given. ©ARKAT USA, Inc.