Time-Lapse Imaging of Neural Stem Cells Exposed to Microgravity on the International Space Station

Abstract

Astronauts who spend significant time in space may experience intracranial hypertension (pressure inside the skull), which often does not normalize upon return to Earth. This type of intracranial pressure can cause vision problems, headaches, glaucoma, and other serious health problems, making it a significant obstacle to long-duration space exploration missions. NASA is hoping that a better understanding of how central nervous system stem cells divide in microgravity will help lead to ways to protect astronauts from problems with intracranial pressure and to design adequate preventive measures. These studies examine cell growth and division of neural stem cells that experienced microgravity on the International Space Station and were returned to normal gravity prior to live-cell imaging studies to determine cell changes.