Sepsis is a disease that affects primarily the aged. Although mortality is higher in both older septic patients and aged septic mice, the mechanisms underlying decreased survival in older hosts are incompletely understood. New work by Inoue and colleagues demonstrates persistent inflammation and T-cell exhaustion in older septic patients and aged septic mice. The clinical significance of these findings is manifested not only in increased mortality but also in a marked difference in secondary infections in older patients as long as a month following ICU admission.
CITATION STYLE
Mittal, R., Ford, M. L., & Coopersmith, C. M. (2014, July 29). Getting older can be exhausting. Critical Care. BioMed Central Ltd. https://doi.org/10.1186/s13054-014-0465-5
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