Cortical surface thickness as a classifier: Boosting for autism classification

Abstract

We study the problem of classifying an autistic group from controls using structural image data alone, a task that requires a clinical interview with a psychologist. Because of the highly convoluted brain surface topology, feature extraction poses the first obstacle. A clinically relevant measure called the cortical thickness has shown promise but yields a rather challenging learning problem - where the dimensionality of the distribution is extremely large and the training set is small. By observing that each point on the brain cortical surface may be treated as a "hypothesis", we propose a new algorithm for LPBoosting (with truncated neighborhoods) for this problem. In addition to learning a high quality classifier, our model incorporates topological priors into the classification framework directly - that two neighboring points on the cortical surface (hypothesis pairs) must have similar discriminative qualities. As a result, we obtain not just a label {+1, -1} for test items, but also an indication of the "discriminative regions" on the cortical surface. We discuss the formulation and present interesting experimental results. © 2008 Springer-Verlag Berlin Heidelberg.