Background. We aimed to determine whether hepatitis B virus (HBV) pre-S deletion was an independent factor for the development of hepatocellular carcinoma (HCC). Methods. Pre-S deletions were determined in HBV isolates from 115 chronic hepatitis B (CHB) patients with HCC. Sixty-nine patients were further matched with 69 CHB patients without HCC for age, sex, hepatitis B e antigen (HBeAg) status, and HBV genotype. Results. HBV pre-S deletions were clustered mainly in the 3′ end of pre-S1 and 5′ end of pre-S2 regions. Adjusted for confounding risk factors, patients with HCC had a higher prevalence of HBV with pre-S deletions than did patients withoutHCC (23 [33.3%] of 69 vs 11 [15.9%] of 69; P=.018; odds ratio [OR], 2.64). In particular, only pre-S2 deletions but not pre-S1 deletions were significantly associated with the development of HCC (P = .020). A higher prevalence of pre-S deletions was observed in HBV isolates from HCC patients under the age of 50 years than fromthose older than 50 years (10 [62.5%] of 16 vs 13 [24.5%] of 53; P = .012; OR, 5.13). Emergence of de novo pre-S deletions was documented before the development of HCC. Conclusions. HBV pre-S2 deletions were an independent factor associated with the development of HCC. Its oncogenic role may be more important in young patients with HCC. © The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.
CITATION STYLE
Yeung, P., Wong, D. K. H., Lai, C. L., Fung, J., Seto, W. K., & Yuen, M. F. (2011). Association of hepatitis B virus pre-S deletions with the development of hepatocellular carcinoma in chronic hepatitis B. Journal of Infectious Diseases, 203(5), 646–654. https://doi.org/10.1093/infdis/jiq096
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