Opioid receptors (MOP-r, KOP-r, DOP-r, as well as NOP-r) and their endogenous neuropeptide agonist systems are involved in diverse neurobiological and behavioral functions, in health and disease. These functions include pain and analgesia, addictions, and psychiatric diseases (e.g., depression-, anxiety-like, and stress-related disorders). Drug discrimination assays have been used to characterize the behavioral pharmacology of ligands with affinity at MOP-r, KOP-r, or DOP-r (and to a lesser extent NOP-r). Therefore, drug discrimination studies with opioid ligands have an important continuing role in translational investigations of diseases that are affected by these neurobiological targets and their pharmacotherapy.
CITATION STYLE
Butelman, E. R., & Kreek, M. J. (2018). Discriminative Stimulus Properties of Opioid Ligands: Progress and Future Directions. In Current Topics in Behavioral Neurosciences (Vol. 39, pp. 175–192). Springer Verlag. https://doi.org/10.1007/7854_2016_9
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