Case Studies in Linear and Nonlinear Modeling

Abstract

This chapter introduces a series of case studies that use linear and nonlinear regression techniques. Allometric scaling and dose proportionality are examined using simple linear regression techniques. Limited sampling and development of a dosing formula for carboplatin are developed using multiple linear regression. The pharmacokinetics of cocaine after intravenous, nasal, and inhalation are studied within the context of a compartmental model using nonlinear weighted least squares, as are the pharmacokinetics of a new chemical entity.