Among the various particulate delivery systems, liposomes-bubble-like nano/microsized lipidic bilayer structures-have shown great promise as an antigen-carrying vehicle. Few liposomal vaccines have been introduced to the market. The key advantages of liposomes as a vaccine delivery system are their ability to protect antigens against degradation, carry single or multiple hydrophilic and lipophilic antigens, control the release of antigens, enhance cellular uptake, and improve antigen-specific immune responses. Physicochemical properties of liposomes such as size, charge, and membrane fluidity can be modified to improve their ability to target antigen-presenting cells. Understanding how the different physicochemical properties of liposomes affect the overall immune response is important for the development of successful liposome-based vaccines. This chapter discusses the use of liposomes as vaccine carriers, the impacts of formulation parameters on liposome-mediated immunity, the different types of liposomes, and their manufacturing perspectives from the bench to large scale.
CITATION STYLE
Nielsen, H. M., Hübschmann, H. B., & Rades, T. (2015). ISCOMs as a Vaccine Delivery System (pp. 141–158). https://doi.org/10.1007/978-1-4939-1417-3_8
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