Background: The relationship between human serum albumin levels and the prognosis of critical care patients with chronic obstructive pulmonary disease (COPD) remains controversial. Objective: To investigate the relationship between serum albumin levels and in-hospital mortality in critical care patients with COPD. METHODS: This study used a retrospective observational cohort from the Medical Information in Intensive Care database (MIMIC-IV) in the United States. Multivariate Cox regression analysis was used to assess the relationship between serum albumin levels and in-hospital mortality. A restricted cubic spline line was also used to explore nonlinear relationship. Results: A total of 3,398 critical care patients with COPD were included. The overall in-hospital mortality was 12.4%. We found a negative relationship between human serum albumin and in-hospital mortality (HR = 0.97, 95% CI 0.96–0.99, p = 0.002). Conclusion: In critical care patients with COPD, there was a negative association between human serum albumin and in-hospital mortality.
CITATION STYLE
Ling, M., Huiyin, L., Shanglin, C., Haiming, L., Zhanyi, D., Shuchun, W., … Murong, L. (2023). Relationship between human serum albumin and in-hospital mortality in critical care patients with chronic obstructive pulmonary disease. Frontiers in Medicine, 10. https://doi.org/10.3389/fmed.2023.1109910
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