Clinical pharmacogenomics

Abstract

OME is from Latin-oma meaning mass. A genome is defined as the complete DNA sequence of an organism, and genomics (also known as functional genomics) is the comprehensive analysis of genomic structure and function. The development of genomics was greatly facilitated by the Human Genome Project and the publication of the draft sequence of the human genome in 2001. This and the development of several enabling technologies such as automated high-throughput DNA sequencing and genotyping, microarray technology, and bioinformatics now allow for complete views of human biological systems including drug activity. These developments have shifted research from gene discovery to the association of specific genes and genetic variants with disease susceptibility, response to therapy, and other phenotypes of importance in healthcare © 2008 Humana Press.