We outline a strategy to use tissue-specific expression along with promoter module analysis to determine the putative functional context of candidate genes implicated in genome-wide association studies. First, genes are selected from candidate SNPs, followed by construction of a gene co-regulation network to expand the regulatory context of the candidate genes, functional analysis to determine putative functional roles, and subsequent analysis of regulatory elements. We describe these sub-strategies and variations, along with guidelines for alternatives in the overall analysis. © 2012 Springer Science+Business Media New York.
CITATION STYLE
Keller, B. J., Martini, S., & Nair, V. (2012). Linking variants from genome-wide association analysis to function via transcriptional network analysis. Methods in Molecular Biology, 910, 297–308. https://doi.org/10.1007/978-1-61779-965-5_13
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