Bioluminescence imaging in the chick chorioallantoic membrane assay

Abstract

For the analysis of tumorigenesis and therapeutic intervention, high throughput technologies that allow the detection of tumor size in the context of a living organism are of need. Here we describe the use of a chorioallantoic membrane model in the developing chick embryo on which growth of a tumor xenograft can be monitored over time, enabling bioluminescence technology.