Cytotoxic steroids from the trunk of Berberis koreana

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Abstract

A new steroid, itesmol 3-O-palmitate (1), along with two known steroids were isolated from the trunk of Berberis koreana. The structure of 1 was determined on the basis of spectroscopic analyses involving 2D NMR and chemical reactions. Compound 1 exhibited potential antiproliferative activity against A549, SK-OV-3, SKMEL- 2, and HCT-15 cell lines (respective IC50 values of 7.41, 9.20, 4.53, and 12.91μM).

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Kim, K. H., Choi, S. U., Kim, C. S., & Lee, K. R. (2012). Cytotoxic steroids from the trunk of Berberis koreana. Bioscience, Biotechnology and Biochemistry, 76(4), 825–827. https://doi.org/10.1271/bbb.110751

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