Mesenchymal stromal cells (MSCs) overexpressing the Wnt3a gene support hematopoiesis at least in part via Wnt-dependent production of extracellular matrix proteoglycans. Canonical Wnt signaling is known to have direct effects on hematopoietic stem cell (HSC) function.
CITATION STYLE
Staal, F. J. T., & Fibbe, W. E. (2012, February 16). Wnt cross-talk in the niche. Blood. American Society of Hematology. https://doi.org/10.1182/blood-2011-12-395863
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