Determinants of antigenicity and specificity in immune response for protein sequences

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Abstract

Target specific antibodies are pivotal for the design of vaccines, immunodiagnostic tests, studies on proteomics for cancer biomarker discovery, identification of protein-DNA and other interactions, and small and large biochemical assays. Therefore, it is important to understand the properties of protein sequences that are important for antigenicity and to identify small peptide epitopes and large regions in the linear sequence of the proteins whose utilization result in specific antibodies.

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Wang, Y., Wu, W., Negre, N. N., White, K. P., Li, C., & Shah, P. K. (2011). Determinants of antigenicity and specificity in immune response for protein sequences. BMC Bioinformatics, 12. https://doi.org/10.1186/1471-2105-12-251

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