Development of a New Hybrid Biodegradable Drug-Eluting Stent for the Treatment of Peripheral Artery Disease

  • Lee J
  • Kim S
  • Park S
  • et al.
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Abstract

This study aimed to develop a new biodegradable stent for peripheral artery disease (PAD) that could provide sufficient radial force to maintain long-term patency and flexibility. All self-expandable hybrid biodegradable stents were designed by using a knitting structure composed of poly-L-lactic acid (PLLA) and nitinol. Four different types of stents were implanted in 20 iliac arteries in 10 mini pigs as follows: a bare-metal stent (BMS) (group 1, n=5 ), a drug-free hybrid stent (group 2, n=5 ), a 50% (50 : 100, w / w ) paclitaxel (PTX)/poly-lactide- co -glycolic acid (PLGA; fast PTX-releasing form) hybrid stent (group 3, n=5 ), and a 30% (30 : 100, w / w ) PTX/PLGA (slow PTX-releasing form) hybrid stent (group 4, n=5 ). We performed follow-up angiography and intravascular ultrasonography (IVUS) at 4 and 8 weeks. In a comparison of groups 1, 2, 3, and 4, less diameter stenosis was observed in the angiographic analysis for group 4 at the 4-week follow-up (19.0% ± 12.7% versus 39.3% ± 18.1% versus 46.8% ± 38.0% versus 4.8% ± 4.2%, resp.; p=0.032 ). IVUS findings further suggested that the neointima of the patients in group 4 tended to be lesser than those of the others. Our new biodegradable 30% PTX/PLGA (slow-releasing form) stent showed more favorable results for patency than the other stent types.

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Lee, J.-H., Kim, S.-J., Park, S.-I., Ko, Y.-G., Choi, D., Hong, M.-K., & Jang, Y. (2016). Development of a New Hybrid Biodegradable Drug-Eluting Stent for the Treatment of Peripheral Artery Disease. BioMed Research International, 2016, 1–7. https://doi.org/10.1155/2016/6915789

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