Dose-dependent effect of Coriandrum sativum Linn. seeds on thermal pain stimulus

Abstract

Aim- To evaluate the analgesic activity of the aqueous and ethanolic extracts Coriandrum sativum (C. sativum) seeds by thermal pain stimulus. Materials & methods- After an acute toxicity study performed as per OECD-425 Guidelines, doses of 100 mg/kg, 250 mg/kg and 500 mg/kg of each extract were selected. Wistar albino rats of either sex (100-200 g) were tested for the mean response time by Eddy’s hot plate method. Statistical significance (p<0.05) was analyzed using ANOVA with post-hoc Dunnett’s test. Results- Both the aqueous and ethanolic extracts showed significant and dose-dependent analgesic activity. The activity of aqueous extracts peaked at 30 min with the mean response time increasing to 5.90s, 5.92s and 6.10s with the 100 mg/kg, 250 mg/kg and 500 mg/kg doses respectively while the activity of ethanolic extracts peaked at 60 min with the mean response time increasing to 5.02s, 6.52s and 6.75s with the 100 mg/kg, 250 mg/kg and 500 mg/kg doses respectively. Conclusion- Coriandrum sativum is a plant with analgesic potential. However, further evaluation is required for analysis of the phytochemical constituents responsible for this activity.