Both cyclin-dependent kinase 5 (Cdk5) and cyclic AMP (cAMP)/protein kinase A (PKA) regulate fundamental central nervous system (CNS) functions including neuronal survival, neurite and axonal outgrowth, neuron development and cognition. Cdk5, a serine/threonine kinase, is activated by p35 or p39 and phosphorylates multiple signaling components of various pathways, including cAMP/PKA signaling. Here, we review the recent literature on the interaction between Cdk5 and cAMP/PKA signaling and their role in the mediation of CNS functions and neuropsychiatric and neurodegenerative diseases.
CITATION STYLE
Hu, Y., Pan, S., & Zhang, H. T. (2017). Interaction of Cdk5 and cAMP/PKA signaling in the mediation of neuropsychiatric and neurodegenerative diseases. In Advances in Neurobiology (Vol. 17, pp. 45–61). Springer New York LLC. https://doi.org/10.1007/978-3-319-58811-7_3
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