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Racial/Ethnic Patterns in Prostate Cancer Outcomes in an Active Surveillance Cohort

  • Cullen J
  • Brassell S
  • Chen Y
  • et al.
Prostate Cancer (2011) 2011 1-9
DOI: 10.1155/2011/234519
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Abstract

Introduction . Concern regarding overtreatment of prostate cancer (CaP) is leading to increased attention on active surveillance (AS). This study examined CaP survivors on AS and compared secondary treatment patterns and overall survival by race/ethnicity. Methods . The study population consisted of CaP patients self-classified as black or white followed on AS in the Center for Prostate Disease Research (CPDR) multicenter national database between 1989 and 2008. Secondary treatment included radical prostatectomy (RP), external beam radiation therapy or brachytherapy (EBRT-Br), and hormone therapy (HT). Secondary treatment patterns and overall survival were compared by race/ethnicity. Results . Among 886 eligible patients, 21% were black. Despite racial differences in risk characteristics and secondary treatment patterns, overall survival was comparable across race. RP following AS was associated with the longest overall survival. Conclusion . Racial disparity in overall survival was not observed in this military health care beneficiary cohort with an equal access to health care.

Figures

  • Figure 1: Kaplan Meier unadjusted estimation curve for time to secondary treatment stratified by race among subjects with prostate cancer (CaP) followed on active surveillance (AS) for primary treatment (N = 886).
  • Figure 2: Kaplan Meier unadjusted estimation curve for overall survival stratified by secondary treatment type among subjects with prostate cancer (CaP) followed on active surveillance (AS) for primary treatment (N = 886).
  • Table 1: Characteristics of subjects with prostate cancer (CaP) followed on active surveillance (AS) for primary treatment, stratified by race (N = 886).
  • Table 2: Characteristics of subjects with prostate cancer (CaP) followed on active surveillance (AS) for primary treatment, stratified by secondary treatment type (N = 886).
  • Figure 3: Kaplan Meier unadjusted estimation curve for overall survival among white men stratified by secondary treatment type among subjects with prostate cancer (CaP) followed on active surveillance (AS) for primary treatment (n = 696).
  • Figure 4: Kaplan Meier unadjusted estimation curve for overall survival among black men stratified by secondary treatment type among subjects with prostate cancer (CaP) followed on active surveillance (AS) for primary treatment (n = 190).
  • Table 3: Multivariable Cox proportional hazards regression predicting overall survival in a cohort of subjects with prostate cancer (CaP) followed on active surveillance (AS) for primary treatment (N = 886).
  • Table 4:Multivariable Cox proportional hazardsmodel predicting overall survival in a cohort of subjects with prostate cancer (CaP) followed on active surveillance (AS) for primary treatment, stratified by secondary treatment type.

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CITATION STYLE

APA

Cullen, J., Brassell, S. A., Chen, Y., Porter, C., L’Esperance, J., Brand, T., & McLeod, D. G. (2011). Racial/Ethnic Patterns in Prostate Cancer Outcomes in an Active Surveillance Cohort. Prostate Cancer, 2011, 1–9. https://doi.org/10.1155/2011/234519

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