The extracellular matrix polysaccharide hyaluronan (HA) exerts size-dependent effects on leukocyte behavior. Low-molecular weight HA is abundant at sites of active tissue catabolism and promotes inflammation via effects on Tolllike receptor signaling. Conversely, high-molecular weight HA is prevalent in uninjured tissues and is anti-inflammatory. We propose that the ability of high-molecular weight but not low-molecular weight HA to cross-link CD44 functions as a novel form of pattern recognition that recognizes intact tissues and communicates "tissue integrity signals" that promote resolution of local immune responses. © Springer Science+Business Media 2014.
CITATION STYLE
Ruppert, S. M., Hawn, T. R., Arrigoni, A., Wight, T. N., & Bollyky, P. L. (2014). Tissue integrity signals communicated by highmolecular weight hyaluronan and the resolution of inflammation. Immunologic Research. Humana Press Inc. https://doi.org/10.1007/s12026-014-8495-2
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