The influence of arterial O2 and CO2 tensions on electroconvulsive seizure duration was investigated in five mongrel dogs under consistent anaesthetic conditions. Seizure durations were measured in a randomized protocol of nine possible combinations of arterial gas tension spanning increased, normal or decreased levels of PaO2 and PaCO2. Seizure duration was directly related to PaO2 (p < 0.00001) and inversely related to PaCO2 (p < 0.0001). A significant synergism was evident at the extremes of PaO2 and PaCO2, with seizure duration being greater than predicted for hyperoxia-hypocapnia and hypoxia-hypercapnia and shorter than predicted for hypoxiahypocapnia and hyperoxia-hypercapnia. We conclude that arterial gas tensions strongly influence ECT-induced seizure duration and through this may influence the therapeutic efficacy of electroconvulsive therapy. © 1987 Canadian Anesthesiologists.
CITATION STYLE
Douglas, C., Butler, P., & Froese, A. (1987). Arterial PaO2 and PaCO2 influence seizure duration in dogs receiving electroconvulsive therapy. Canadian Journal of Anaesthesia, 34(5), 437–441. https://doi.org/10.1007/BF03014344
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