Rheological Methods to Evaluate the Efficacy of a New Compounding to Diagnose the Olfactory Dysfunction

Abstract

The assessment of olfactory dysfunction (partial or total anosmia) is important in the early diagnosis of neurodegenerative diseases and may be a good indicator in clinical diagnosis. Currently, there is no diagnostic test for partial or total anosmia validated for the Portuguese population. The aim of this study was the development and rheological and sensory characterization of hospital compounded formulations containing 23 different fragrances adapted to Portuguese population. During the studies, several PEG-based formulations were developed. Viscoelasticity assays were performed in the Rheometer Kinexus using the oscillatory method. Differential scanning calorimeter and microscopy were assessed as well as the volatile components analysis by GC-MS. Thus, a new compounding for the diagnosis of olfactive dysfunction with a structured and rheological characteristic adapted to the Portuguese population were developed.