Antisense-Mediated Reduction of Eukaryotic Noncoding RNAs

Abstract

The human genome has been demonstrated to be transcribed largely as noncoding RNAs. Accumulating evidence suggests important roles for many noncoding RNAs in different biological processes as well as in human diseases. Thus, it is important to be able to manipulate the expression of the noncoding RNAs, both for biological functionalization of these RNAs and for treatment of diseases related to noncoding RNAs. In this review, we summarize the approaches for reducing expression of noncoding RNAs in different eukaryotic organisms and the insights provided into the functions of these noncoding RNAs.