Risk factors for computed tomography angiography spot sign in deep and lobar intracerebral hemorrhage are shared

26Citations
Citations of this article
40Readers
Mendeley users who have this article in their library.

Abstract

Background and Purpose: Patients with intracerebral hemorrhage (ICH) who present with a spot sign on computed tomography angiography are at increased risk of hematoma expansion and poor outcome. Because primary ICH is the acute manifestation of chronic cerebral small vessel disease, we investigated whether different clinical or imaging characteristics predict spot sign presence, using ICH location as a surrogate for arteriolosclerosis-and cerebral amyloid angiopathy-related ICH. METHODS-: Patients with primary ICH and available computed tomography angiography at presentation were included. Predictors of spot sign were assessed using uni-and multivariable regression, stratified by ICH location. RESULTS-: Seven hundred forty-one patients were eligible, 335 (45%) deep and 406 (55%) lobar ICH. At least one spot sign was present in 76 (23%) deep and 102 (25%) lobar ICH patients. In multivariable regression, warfarin (odds ratio [OR], 2.42; 95% confidence interval [CI], 1.01-5.71; P=0.04), baseline ICH volume (OR, 1.20; 95% CI, 1.09-1.33, per 10 mL increase; P<0.001), and time from symptom onset to computed tomography angiography (OR, 0.89; 95% CI, 0.80-0.96, per hour; P=0.009) were associated with the spot sign in deep ICH. Predictors of spot sign in lobar ICH were warfarin (OR, 3.95; 95% CI, 1.87-8.51; P<0.001) and baseline ICH volume (OR, 1.20; 95% CI, 1.10-1.31, per 10 mL increase; P<0.001). CONCLUSIONS-: The most potent associations with spot sign are shared between deep and lobar ICH, suggesting that the acute bleeding process that arises in the setting of different chronic small vessel diseases shares commonalities. © 2014 American Heart Association, Inc.

References Powered by Scopus

Prediction of haematoma growth and outcome in patients with intracerebral haemorrhage using the CT-angiography spot sign (PREDICT): A prospective observational study

524Citations
N/AReaders
Get full text

Contrast extravasation on CT angiography predicts hematoma expansion in intracerebral hemorrhage

289Citations
N/AReaders
Get full text

Systematic characterization of the computed tomography angiography spot sign in primary intracerebral hemorrhage identifies patients at highest risk for hematoma expansion: the spot sign score.

196Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Cerebral amyloid angiopathy: Emerging concepts

285Citations
N/AReaders
Get full text

Intensive blood pressure reduction and spot sign in intracerebral hemorrhage: A secondary analysis of a randomized clinical trial

95Citations
N/AReaders
Get full text

Association between serum calcium level and extent of bleeding in patients with intracerebral hemorrhage

88Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Radmanesh, F., Falcone, G. J., Anderson, C. D., Battey, T. W. K., Ayres, A. M., Vashkevich, A., … Brouwers, H. B. (2014). Risk factors for computed tomography angiography spot sign in deep and lobar intracerebral hemorrhage are shared. Stroke, 45(6), 1833–1835. https://doi.org/10.1161/STROKEAHA.114.005276

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 16

59%

Researcher 7

26%

Professor / Associate Prof. 3

11%

Lecturer / Post doc 1

4%

Readers' Discipline

Tooltip

Medicine and Dentistry 21

72%

Neuroscience 5

17%

Biochemistry, Genetics and Molecular Bi... 2

7%

Chemistry 1

3%

Save time finding and organizing research with Mendeley

Sign up for free