Sublingual nifedipine in human pregnancy

Abstract

Background: Nifedipine is widely used for acute lowering of blood pressure in obstetric hypertensive emergencies. It has not been approved for this indication or widely assessed. Aims: To examine retrospectively the efficacy of nifedipine over a 12 month period in a high risk obstetric service. Methods: Chart review of all patients admitted to hospital in the antenatal period with moderate to severe hypertension. Description of their management, usage of nifedipine, and pregnancy outcome. Results: Sublingual nifedipine resulted in significant lowering of blood pressure without hypotension. Pregnancy outcome was satisfactory in all patients. Conclusions: Sublingual nifedipine was effective, easy to administer, and without serious complications in this retrospective study.