A 61-year-old ex-boxer presented with a three-year history of progressive memory decline. During a seven-year follow-up period, there was a continuous cognitive decline, very similar to that usually observed in Alzheimer's disease. Parkinsonian, pyramidal or cerebellar signs were conspicuously absent. Neuropathological examination revealed the typical features of dementia pugilistica: cavum septi pellucidi with multiple fenestrations, numerous neurofibrillary tangles in the cerebral isocortex and hippocampus (and rare senile plaques). Immunohistochemistry disclosed a high number of tau protein deposits and scarce beta-amyloid staining. This case shows that dementia pugilistica may present with clinical features practically undistinguishable from Alzheimer's disease.
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Areza-Fegyveres, R., Rosemberg, S., Castro, R. M. R. P. S., Porto, C. S., Bahia, V. S., Caramelli, P., & Nitrini, R. (2007). Dementia Pugilistica with clinical features of Alzheimer’s disease. Arquivos de Neuro-Psiquiatria, 65(3 B), 830–833. https://doi.org/10.1590/S0004-282X2007000500019