Abscopal regression of hepatocellular carcinoma after radiotherapy for bone metastasis

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Abstract

Spontaneous regression of hepatocellular carcinoma is a rare phenomenon. Abscopal regression of turnouts resulting from the effect of irradiation of a tissue on a remote non-irradiated tissue is also rare. The case of a 76 year old Japanese man with hepatocellular carcinoma that regressed after radiotherapy for thoracic vertebral bone metastasis is described. Serum levels of turnout necrosis factor-α increased after radiotherapy. The findings suggests that such abscopal related regression may be associated with host immune response, involving cytokines such as tumour necrosis factor-α.

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Ohba, K., Omagari, K., Nakamura, T., Ikuno, N., Saeki, S., Matsuo, I., … Kohno, S. (1998). Abscopal regression of hepatocellular carcinoma after radiotherapy for bone metastasis. Gut, 43(4), 575–577. https://doi.org/10.1136/gut.43.4.575

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