Abstract
Purpose: CD5 is a T cell marker, aberrantly express in B cell chronic lymphocytic leukemia (B-CLL) and mantle cell lymphoma (MCL). Other chronic B cell malignancies including hairy cell leukemia (HCL) and B cell prolymphocytic leukemia (B-PLL) are CD5 negative or express this antigen in a weak way. In this study, CD5 expression was investigated in leukemic cells from 42 patients with chronic B cell lymphoproliferative disease. Methods: We studied the CD5 expression in leukemic cells from 42 patients with chronic B-cell malignancies by flow cytometry. Demographic features such as age, sex and clinical date were also analyzed. Results: There were 22 males and 20 females. The immunophenotyping showed that 35 cases were B-CLL, 3 B-PLL and HCL and one patient was MCL. CD5 expression was present in all B-CLL and MCL. Low expression of CD5 was observed in one patient with B-PLL and negative in all cases of HCL. Conclusion: Our date demonstrated that CD5 expression can help distinguish among B-CLL from HCL and B-PLL, but is similar expressed in MCL.
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Barroso Cavalcanti, G., De Farias Sales, V. S., Kramer Cavalcanti E Silva, D. G., De Araújo Lopes, M. C., De Souza Paiva, A., Macedo Da Fonseca, H. E., … Fernandes, M. Z. (2005). Detection of CD5 in B-cell chronic lymphoproliferative diseases by flow cytometry: A strong expression in B-cell chronic lymphocytic leukemia. In Acta Cirurgica Brasileira (Vol. 20, pp. 56–62). Sociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgia. https://doi.org/10.1590/s0102-86502005000700011
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