Extensive and spatially variable withincell-type heterogeneity across the basolateral amygdala

39Citations
Citations of this article
98Readers
Mendeley users who have this article in their library.
Get full text

Abstract

The basolateral amygdala complex (BLA), extensively connected with both local amygdalar nuclei as well as long-range circuits, is involved in a diverse array of functional roles. Understanding the mechanisms of such functional diversity will be greatly informed by understanding the cell-type-specific landscape of the BLA. Here, beginning with single-cell RNA sequencing, we identified both discrete and graded continuous gene-expression differences within the mouse BLA. Via in situ hybridization, we next mapped this discrete transcriptomic heterogeneity onto a sharp spatial border between the basal and lateral amygdala nuclei, and identified continuous spatial gene-expression gradients within each of these regions. These discrete and continuous spatial transformations of transcriptomic cell-type identity were recapitulated by local morphology as well as long-range connectivity. Thus, BLA excitatory neurons are a highly heterogenous collection of neurons that spatially covary in molecular, cellular, and circuit properties. This heterogeneity likely drives pronounced spatial variation in BLA computation and function.

References Powered by Scopus

Get full text
28552Citations
16510Readers

This article is free to access.

This article is free to access.

Cited by Powered by Scopus

62Citations
211Readers
Get full text

This article is free to access.

This article is free to access.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

O’leary, T. P., Sullivan, K. E., Wang, L., Clements, J., Lemire, A. L., & Cembrowski, M. S. (2020). Extensive and spatially variable withincell-type heterogeneity across the basolateral amygdala. ELife, 9, 1–27. https://doi.org/10.7554/ELIFE.59003

Readers over time

‘20‘21‘22‘23‘2409182736

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 35

64%

Researcher 17

31%

Professor / Associate Prof. 3

5%

Readers' Discipline

Tooltip

Neuroscience 40

63%

Agricultural and Biological Sciences 12

19%

Biochemistry, Genetics and Molecular Bi... 8

13%

Psychology 3

5%

Save time finding and organizing research with Mendeley

Sign up for free
0