No increase in free fetal DNA level in ectopic pregnancy: A preliminary study

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Abstract

Objective: The aim of this study was to diagnose ectopic pregnancy in the early period by measuring cell-free fetal DNA (cffDNA) levels in maternal blood using spectrophotometry. Materials and Methods: Thirty patients with ectopic pregnancy and 30 patients with first trimester intrauterine pregnancy were enrolled in this prospective controlled study. cffDNA levels in maternal serum were measured using spectrophotometry. Results: There were no differences between the two groups in terms of cffDNA absorbance levels. Conclusion: Spectrophotometry is not suitable for measuring cffDNA levels to diagnose ectopic pregnancies in the early period. Practical and cost-effective methods should be found or larger patient series should be investigated.

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Karuserci, Ö. K., Uğur, M. G., Balat, Ö., & Sucu, S. (2017). No increase in free fetal DNA level in ectopic pregnancy: A preliminary study. Turkish Journal of Obstetrics and Gynecology, 14(3), 156–159. https://doi.org/10.4274/tjod.54715

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