Human Cytomegalovirus is the Cause of Glioblastoma Multiforme

Abstract

Objective: The relationship between Human cytomegalovirus (HCMV) and glioblastoma multiforme (GBM) is investigated. Methods: A systematic review and re-analysis of some impressive key studies was conducted aimed to answer the following question. Is there a cause-effect relationship between HCMV and GBM? The method of the conditio sine qua non relationship was used to proof the hypothesis whether the presence of HCMV guarantees the presence of GBM. In other words, without HCMV no GBM. The mathematical formula of the causal relationship k was used to proof the hypothesis, whether there is a cause-effect relationship between HCMV and GBM. Significance was indicated by a p-value of less than 0.05. Results: The studies analysed were able to provide strict evidence that HCMV is a necessary condition (a conditio sine qua non) of GBM. Furthermore, the cause-effect relationship between HCMV and GBM (k ~ + 0.8608, p value < 0.0001) was highly significant. Conclusion: Without a human cytomegalovirus infection no glioblastoma multiforme. Human cytomegalovirus is the cause of glioblastoma multiforme.