Desarrollo de un neuroestimulador para estudios de crisis epilépticas

Abstract

In this paper we present the development and use of an electrical physiological stimulator multichannel programmable. This stimulator was especially used in studies for detecting epileptic events and crisis prediction through rats' electroencephalograms. The animals were followed by the kindling model. The system allows to program different stimulation parameters (Wide of pulse, Separation between successive pulses, Intensity, Number of applied pulses total). Accurately limited and in digital form. This stimulator generates bipolar constant current pulses with maximum amplitude of 5 mA and resolution 50 uA, allowing a voltage with maximum amplitude of 150 V. The stimulator was made with and microcontroller (PIC18F4550) and if is controlled by PC. Rats were used on testing achieving epileptic events. © Springer-Verlag Berlin Heidelberg 2007.