One-pot synthesis of fluorinated 2-arylchroman-4-one derivatives from 2-(triisopropylsilyl)ethynylphenols and aromatic aldehydes

Abstract

A facile p-toluenesulfonic acid–catalyzed one-pot synthesis of biologically interesting fluorinated 2-arylchroman-4-one derivatives from 2-(triisopropylsilyl)ethynylphenols and aromatic aldehydes is described. This synthetic method is metal-free, operationally simple, cheap and productive. It provides a rapid access to the title compounds as well as their 3-benzylidene and 8-cinnamoyl derivatives, that are of interest as objects for the evaluation of their pharmacological properties.