Potential utility of PPARα activation in the prevention of ischemic and drug-induced acute renal damage

Abstract

Acute renal failure induced by renal ischemia or drugs continues to be a relevant clinical problem. Li et al. have demonstrated that proximal tubule-restricted peroxisome proliferator-activated receptor-α (PPARα) expression in transgenic mice reduced cisplatin-and ischemia/reperfusion-induced acute renal injury. Their article suggests a role for the maintenance of free fatty acid oxidation in the proximal tubule as a mechanism of nephroprotection, as well as a potential clinical utility of PPARα activators in the prevention of acute renal failure. © 2009 International Society of Nephrology.