Synthesis of biocompatible multicolor luminescent carbon dots for bioimaging applications

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Abstract

Water-soluble carbon dots (C-dots) were prepared through microwave-assisted pyrolysis of an aqueous solution of dextrin in the presence of sulfuric acid. The C-dots produced showed multicolor luminescence in the entire visible range, without adding any surface-passivating agent. X-ray diffraction and Fourier transform infrared spectroscopy studies revealed the graphitic nature of the carbon and the presence of hydrophilic groups on the surface, respectively. The formation of uniformly distributed C-dots and their luminescent properties were, respectively, revealed from transmission electron microscopy and confocal laser scanning microscopy. The biocompatible nature of C-dots was confirmed by a cytotoxicity assay on MDA-MB-468 cells and their cellular uptake was assessed through a localization study. © 2012 National Institute for Materials Science.

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Puvvada, N., Kumar, B. N. P., Konar, S., Kalita, H., Mandal, M., & Pathak, A. (2012). Synthesis of biocompatible multicolor luminescent carbon dots for bioimaging applications. Science and Technology of Advanced Materials, 13(4). https://doi.org/10.1088/1468-6996/13/4/045008

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