The etiology of osteosarcoma (OS) remains enigmatic. Particular clinical and molecular patterns, observed with high frequency in OS, suggest that it results from some yet-to-be-discovered central driver. How else can biology generate such an aggressive, metastatic, genetically and chromosomally unstable malignancy with virtually no apparent precursor neoplasms that are partway along a disease path toward OS? With this conundrum as a backdrop, the discovery of every new native molecule with power to impact a cell's biology is usually quickly followed by a search to see if this type of molecule contains the key to unlock OS biology.
CITATION STYLE
Kafchinski, L. A., & Jones, K. B. (2014). MicroRNAs in osteosarcomagenesis. Advances in Experimental Medicine and Biology, 804, 119–127. https://doi.org/10.1007/978-3-319-04843-7_6
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