Ganoderma lucidum Polysaccharide Peptide (GLPP) for the Cancer Treatment

Abstract

Ganoderma lucidum mushroom (also known as Ling Zhi in China, Mannetake /Reishi in Japan) has been widely used for thousands of years to prevent and treat various diseases, such as heart disease, diabetes mellitus, viral infection, and cancer. Polysaccharides from Ganoderma lucidum has been extensively investigated for free radical scavenging activity. Both in vivo and in vitro studies suggest that G. lucidum have anti-tumor effects, which mediated by its immunomodulatory, anti-angiogenesis, and cytotoxic effects. Ganoderma lucidum polysaccharide peptide (GLPP) which extracted from Ganoderma lucidum mycelium tissue culture, give the best quality of β-D-Glucans bioactive compounds. These biologically active glucans interact with receptors on the surface of immune cells such as macrophage and natural killer cell (NK cell) to induce immunomodulatory and tumoricidal effects. However, many studies still need to answer those mechanisms.