Pediatric MDS: GATA screen the germline

4Citations
Citations of this article
26Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

In this issue of Blood, Wlodarski and colleagues demonstrate that as many as 72% of adolescents diagnosed with myelodysplastic syndrome (MDS) and monosomy 7 harbor germline mutations in GATA2.1 Although pediatric MDS is a very rare diagnosis, occurring in 0.8 to 4 cases per million,2 Wlodarski et al screened >600 cases of primary or secondary MDS in children and adolescents who were enrolled in the European Working Group on MDS consortium over a period of 15 years. The overall frequency of germline GATA2 mutations in children with primary MDS was 7%, and 15% in those presenting with advanced disease. Notably, mutations in GATA2 were absent in patients with therapy-related MDS or acquired aplastic anemia.

Cite

CITATION STYLE

APA

Stieglitz, E., & Loh, M. L. (2016, March 17). Pediatric MDS: GATA screen the germline. Blood. American Society of Hematology. https://doi.org/10.1182/blood-2016-01-690016

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free