Dihydroisocoumarins from the mangrove-derived fungus Penicillium citrinum

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Abstract

Three new dihydroisocoumarin penicimarins G-I (1-3), together with one<br />known dihydroisocoumarin (4) and three known meroterpenoids (5-7), were<br />obtained from a fungus Penicillium citrinum isolated from the mangrove<br />Bruguiera sexangula var. rhynchopetala collected in the South China Sea.<br />Their structures were elucidated by the detailed analysis of<br />spectroscopic data. The absolute configuration of 1 was determined by<br />the X-ray diffraction analysis using Cu K radiation. The absolute<br />configurations of 2 and 3 were determined by comparison of their<br />circular dichroism (CD) spectra with the literature. All compounds were<br />evaluated for their antibacterial activities and cytotoxic activities.

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Huang, G. L., Zhou, X. M., Bai, M., Liu, Y. X., Zhao, Y. L., Luo, Y. P., … Chen, G. Y. (2016). Dihydroisocoumarins from the mangrove-derived fungus Penicillium citrinum. Marine Drugs, 14(10). https://doi.org/10.3390/md14100177

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