Direct cardiovascular effects of glucagon like peptide-1

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Abstract

Glucagon-like peptide-1 (GLP-1) is involved in satiety control and glucose homeostasis. Besides, GLP-1 has cardiovascular effects. In experimental models, GLP-1 increases cardiac output and exerts a direct vasodilatory effect. In animals with dilated cardiomyopathy GLP-1 improves left ventricular performance. Human data demonstrated that GLP-1 reduces arterial blood pressure, improves endothelial function in individuals with diabetes and left ventricular function in patients with heart failure. Administration of GLP-1 increases ejection fraction in acute myocardial infraction and reduces ischemia-reperfusion myocardial injury. Although more research is needed, these data suggest that GLP-1 may be used with promising results in patients with heart failure, acute myocardial infarction and revascularization procedures in addition to the standard therapy. © 2011 Bentham Science Publishers Ltd.

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APA

Sheikh, A. (2013). Direct cardiovascular effects of glucagon like peptide-1. Diabetology and Metabolic Syndrome. https://doi.org/10.1186/1758-5996-5-47

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