DNA binds neutrophil elastase and mucus proteinase inhibitor and impairs their functional activity

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Abstract

DNA binds neutrophil elastase and mucus proteinase inhibitor as evidenced by affinity chromatography on elastase-Sepharose, inhibitor-Sepharose and DNA-cellulose. DNA is a potent hyperbolic inhibitor of elastase. The polynucleotide-enzyme complex is partially active on synthetic substrates and on elastin. DNA strongly increases kdiss and Ki for the inhibition of elastase by mucus proteinase inhibitor {A figure is presented} The above effects are all salt-dependent. At physiological ionic strength, DNA is a potent inhibitor of the elastolytic activity of elastase and increases kdiss and Ki for the elastase-mucus proteinase inhibitor interaction 160-fold and 100-fold, respectively. © 1995.

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Belorgey, D., & Bieth, J. G. (1995). DNA binds neutrophil elastase and mucus proteinase inhibitor and impairs their functional activity. FEBS Letters, 361(2–3), 265–268. https://doi.org/10.1016/0014-5793(95)00173-7

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